• Understanding and Reversing Chronic Radiation Dermatitis: A Prospective Study
DO YOU HAVE FIBROSIS ASSOCIATED WITH RADIATION?


You may qualify for a RESEARCH STUDY to evaluate the safety and effectiveness of a treatment that may improve the hardening or fibrosis associated with chronic radiation injury using a fractional carbon dioxide (CO2) laser. Fractional laser is widely used to treat scars, and is approved by the FDA for treating scars. This procedure involves using a laser to create tiny holes on the skin that will heal in about 5-7 days. It has a few minor side effects that are most often temporary. An important question being tested in this study is whether this treatment can improve the skin hardening associated with chronic radiation injury.

• Healthy males and females between 18 and 70 years of age with radiation-induced fibrosis for at least one year.
• Having suitable areas of treatment: All wounds in the area of interest must be closed for at least two months. The scars must be stable for a period of 3 months.
• Able and willing to comply with all visit, treatment and evaluation schedules and requirements
• Able to understand and provide written informed consent.
• Photos, measurements of the color of the scar at enrollment and treatment with laser. There will be a treated and non-treated area. Subject will be offered the best treatment at end of study.
• Up to 10 study visits, less than 1 hour each, over two years period
• Up to $445 (with 2 small skin biopsies) or $295 (without) in compensation for time and travel (parking sticker will also be provided)
• The study will be carried out at the Wellman Center for Photomedicine’s Clinical Research Center at the Massachusetts General Hospital

For more information, please email:
Ttran2@partners.org or call 617-724-4937
More information can be found at:
http://www2.massgeneral.org/wellman/
Institution  –  MGH - Massachusetts General Hospital, Boston, MA; BWH - Brigham and Women's Hospital, Boston, MA; NWH, Newton, MA; Spaulding Rehab. Hospital, Boston, MA; DFCI, Boston, MA; North Shore Medical Center, Salem, MA; Beth Israel Deaconess, Boston, MA; Boston University Medical Center, Boston, MA; MIT, Cambridge, MA; Massachusetts General Hospital - East, Charlestown, MA
Principal Investigator  – Richard R Anderson, MD
  
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Thanh Nga T Tran, MD PhD
Email  – ttran2@partners.org
Phone  – 617 724 4937