• Comparison of LANTUS and NPH in The DAWN PHENOMENON
Subject: Comparison of Lantus and NPH Insulin in the Dawn Phenomenon
Massachusetts General Hospital, Diabetes Research Center, seeks individuals with Type 1 diabetes for a research study to better understand how two different types of long-acting insulin affect blood sugar control during the early morning hours. Study involves: 1. Three daytime outpatient visits at the Diabetes Research Center, including nutritional counseling, teaching of the Continuous Glucose Monitoring System(CGMS). 2. Two overnight inpatient hospital stays during which blood samples will be obtained through an intravenous (in the vein) line. Study requirements: Candidates must have Type 1 diabetes for 5 or more years, be between the ages of 18-60, and must use either glargine (lantus) or NPH insulin. Compensation: Up to $220. All tests and alternate insulins provided at no cost. For more info :Christine Stevens RN, study coordinator at 617-643-0915. IRB#2005-p-002515
Institution  –  MGH - Massachusetts General Hospital, Boston, MA
Principal Investigator  – David M Nathan, MD
  
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Christine R Stevens, RN
Email  – cstevens@partners.org
Phone  – 6176430915

About Type 1 Diabetes:
Type 1 diabetes accounts for 5 to 10 percent of all diagnosed cases of diabetes in the US. Type 1 diabetes usually develops in children or young adults, but can start at any age. It may also be known by a variety of other names, including the following:
  • insulin-dependent diabetes mellitus (IDDM)
  • juvenile diabetes
  • brittle diabetes
  • sugar diabetes
There are two forms of type 1 diabetes:
  • idiopathic type 1 diabetes - refers to rare forms of the disease with no known cause.
  • immune-mediated diabetes - an autoimmune disorder in which the body's immune system destroys, or attempts to destroy, the cells in the pancreas that produce insulin. Immune-mediated diabetes is the most common form of type 1 diabetes, and the one generally referred to as type 1 diabetes. The information on this page refers to this form of type 1 diabetes.