• Physiologic Investigation of the Renin-Angiotensin-Aldosterone Axis in HIV
This research study aims to explore the effects of aldosterone, a mineralocorticoid hormone associated with water reabsorption, on visceral adipose tissue and insulin sensitivity in persons with HIV infection who have metabolic complications such as bigger belly and elevated blood sugar levels. The results of this study may be important in developing new treatment strategies for metabolic abnormalities in HIV.

This study consists of a total of 4 visits, 1 screening visit to determine eligibility and 3 subsequent visits for those who qualify (three of which are overnight visits). Study visits include evaluation of health history, glucose tolerance test, blood draw, insulin sensitivity test, full body DEXA scan, MRI scan of abdominal fat, as well as some additional study specific procedures that will be explained upon inquiry. Subjects will be compensated for their time and effort with up to $450. Transportation will be reimbursed and parking will be paid for. Meals and meal tickets will be provided during study visits.

Recruitment Status: OPEN

Eligibility Criteria: HIV positive males and females and HIV negative males and females, ages 18-65. Other requirements for participation to be explained by study contact.
Institution  –  MGH - Massachusetts General Hospital, Boston, MA; BWH - Brigham and Women's Hospital, Boston, MA
Principal Investigator  – Steve Grinspoon, MD
  
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Suman Srinivasa, MD
Email  – sz806@partners.org
Phone  – 617-726-1585