• Pharmacokinetic Comparison of Insulin and Glucagon Delivery in Volunteers with Type 1 Diabetes
Pharmacokinetic Comparison of Insulin and Glucagon Delivery in Volunteers with Type 1 Diabetes
A Comparison of Insulin and Glucagon Injection Devices

Researchers at the Massachusetts General Hospital Diabetes Research Center are recruiting subjects to determine if new types of injection devices speed up the action of insulin and glucagon.

You may be eligible if:

•You are 18 years or older
•You have had type 1 diabetes for at least 1 year
•You are using an insulin pump

The study involves a short screening visit to determine eligibly. If you chose to participate you will be asked to complete two 6.5 hour study visits at the Diabetes Research Center. During the visit an IV catheter will be placed and you will be bolused with insulin for a meal using a traditional needle during one visit and a microneedle, which delivers insulin and glucagon under the skin, during the other. Two small doses of glucagon will also be administered during each visit. We will check your blood glucose and draw blood using the IV frequently throughout each study visit.

Parking validation and a meal voucher will be provided. You will receive $50 for completing the screening visit and $100 for each study visit for a total of $250 compensation.

For more information please contact:
Mallory Hillard at mahillard@partners.org or 617-643-2019
Institution  –  MGH - Massachusetts General Hospital, Boston, MA
Principal Investigator  – Steven J Russell, MD, PhD
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Mallory A Hillard
Phone  – 617-643-2019

About Type 1 Diabetes:
Type 1 diabetes accounts for 5 to 10 percent of all diagnosed cases of diabetes in the US. Type 1 diabetes usually develops in children or young adults, but can start at any age. It may also be known by a variety of other names, including the following:
  • insulin-dependent diabetes mellitus (IDDM)
  • juvenile diabetes
  • brittle diabetes
  • sugar diabetes
There are two forms of type 1 diabetes:
  • idiopathic type 1 diabetes - refers to rare forms of the disease with no known cause.
  • immune-mediated diabetes - an autoimmune disorder in which the body's immune system destroys, or attempts to destroy, the cells in the pancreas that produce insulin. Immune-mediated diabetes is the most common form of type 1 diabetes, and the one generally referred to as type 1 diabetes. The information on this page refers to this form of type 1 diabetes.