• Investigation of cortico-limbic networks and their dynamics in major depressive disorder
Subjects Wanted for A Research Study of Brain Networks in Depression

Dr. Mark Eldaief of the Brigham and Women’s Hospital is conducting a research study to examine brain network function in individuals with depression.
The study will take place at the Martinos Center of the Massachusetts General Hospital at the Charlestown Navy Yard. It will occur over three to four study visits, each lasting about 2 to 4 hours. Visits will be spread over two months.
The study involves obtaining “pictures” of your brain with two different methods: functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) and receive a form of non-invasive brain stimulation called Transcranial Magnetic Stimulation (TMS).

In order to participate you must:
1. Have been diagnosed with depression or have significant symptoms of depression for at least 2 weeks including: low mood, decreased interest, an inability to experience pleasure, poor energy levels or appetite, insomnia, or feelings of guilt or death.
2. Have NOT started a medication for depression.
3. Be between the ages of 18-50.
4. Have no other psychiatric disorders (e.g. bipolar disorder, schizophrenia) and not currently taking any other psychiatric medications (e.g. a mood stabilizer).
5. Have no neurological disorders (e.g. epilepsy, stroke). You also cannot have any first-degree relatives with seizures or epilepsy.
6. NOT be taking any street drugs (e.g. marijuana, heroin, cocaine).
7. NOT have any of the following: pacemakers, aneurysm clips, or other metallic objects in your body.
8. NOT have had a PET scan recently.
9. NOT be currently pregnant, or think that you might be pregnant.

Participants will be paid up to $400 for their time. Parking and public transportation
costs will also be covered by the study, as will all scanning procedures and TMS.

If interested please email meldaief@partners.org
Institution  –  MGH - Massachusetts General Hospital, Boston, MA; BWH - Brigham and Women's Hospital, Boston, MA
Principal Investigator  – Mark C Eldaief, MD
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Mark C Eldaief, MD
Email  – meldaief@partners.org
Phone  – (917) 446-4837