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  • EndoBarrier: a Novel therapy for type 2 Diabetes in Obese adults (The ENDO Trial)
Type 2 Diabetes: The EndoBarrier Study

• Do you have type 2 diabetes?
• Do you take only oral medications to treat it?
• Are you overweight?
• Are you age 21-65?

If yes, you could be eligible for a study of a new, investigational device to lower blood sugar and help with weight loss. The EndoBarrier device is a thin, flexible, tube-shaped liner that forms a physical barrier between the food you eat and a portion of the intestinal wall. Study subjects are randomly assigned to receive either the device, which is placed endoscopically (a non-surgical procedure) in the small intestine or to have a sham procedure.

Subjects come to 10-12 study visits over 12-18 months and receive, at no cost:

• Diabetes medical management by study doctors
• Blood tests, bone density scan, chest X-ray, EKG
• Nutrition counseling for diabetes and weight control

Compensation for time and travel expenses is provided

For more information, please call Laurie Bissett, MS RDN at 617-726-1687
lbissett@partners.org
MGH Diabetes Research Center
Institution  –  MGH - Massachusetts General Hospital, Boston, MA
Principal Investigator  – Enrico Cagliero, MD
  
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Laurie Bissett, CRC
Email  – lbissett@partners.org
Phone  – 617-726-1687

About Diabetes:
Type 1 diabetes accounts for 5 to 10 percent of all diagnosed cases of diabetes in the US. Type 1 diabetes usually develops in children or young adults, but can start at any age. It may also be known by a variety of other names, including the following:
  • insulin-dependent diabetes mellitus (IDDM)
  • juvenile diabetes
  • brittle diabetes
  • sugar diabetes
There are two forms of type 1 diabetes:
  • idiopathic type 1 diabetes - refers to rare forms of the disease with no known cause.
  • immune-mediated diabetes - an autoimmune disorder in which the body's immune system destroys, or attempts to destroy, the cells in the pancreas that produce insulin. Immune-mediated diabetes is the most common form of type 1 diabetes, and the one generally referred to as type 1 diabetes. The information on this page refers to this form of type 1 diabetes.
Type 2 diabetes is a metabolic disorder resulting from the body's inability to make enough, or to properly use, insulin. It used to be called non-insulin-dependent diabetes mellitus (NIDDM).
Without adequate production or utilization of insulin, the body cannot move blood sugar into the cells. It is a chronic disease that has no known cure. It is the most common type of diabetes, accounting for 90 to 95 percent of diabetes cases.