• Genotype and Phenotype of Brainstem Injury in Autism, Project IV: Gene-environment interactions in a population exposed to a teratogen associated with autism
Children exposed to Valproic Acid (Brand Name: Depakote)

The Genetics Unit of Massachusetts General Hospital is looking for healthy children who were exposed to the anticonvulsant drug, valproate, before birth. There has been some concern that prenatal exposure to this drug increases the risk for Autism Spectrum Disorders (ASDs) in some children. We are studying whether the effects of exposure to valproate during pregnancy depend on the child’s genetic makeup (the presence of certain genes).

To participate in this study, the children must be at least 2 years of age. The brief exam is primarily of the face and hands. Additionally, we ask to take pictures and obtain DNA samples via saliva or cheek swab. This examination is approximately 30 minutes and can be done here at the hospital or in the privacy of your home. You child is paid $50 for participating, and you will be compensated for your travel expenses to the hospital.

If you are interested in participating or would like more information, please contact Hanah Nasri by calling 617-724-1252 or by e-mail at hnasri@partners.org.
Institution  –  MGH - Massachusetts General Hospital, Boston, MA
Principal Investigator  – Lewis B Holmes, MD
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Hanah Nasri
Email  – hnasri@partners.org
Phone  – 617-724-1252