• Circadian rhythms and sleep-wake cycles in Parkinson’s Disease
Patients who have been diagnosed with Parkinson’s disease and are over the age of 50 are needed for a research study on circadian rhythms and sleep-wake cycles in Parkinson’s disease. We are also recruiting healthy controls.

Participants will come for one screening visit, and if eligible, an inpatient visit to the hospital for 3 nights. We will take blood samples to assess melatonin and “clock gene” levels, as well as conduct a sleep study. Parkinson’s patients with significant sleep problems will be asked to return for a second inpatient visit after a few weeks of exposure to a bright light therapy lamp. This is being done to look at the effects that exposure to a bright light has on daytime sleepiness and night-time sleep in Parkinson’s disease. You will be paid up to $50.00 for each night spent in the CRC, for a possible total of $300.00. You will receive parking vouchers to cover parking expenses related to the study visits.

If you are interested in participating, please review the criteria below, or if you would like to learn more about this study please contact Catherine Havemann by phone at (617) 726-9589 or by email at chavemann@mgh.harvard.edu

Parkinson’s patients should:
- Have a diagnosis of idiopathic Parkinson’s disease (or healthy control)
- Be on a stable dose of PD medication for at least 4 weeks prior to the
screening (or healthy control)
- Be 50+ years of age

You may not be eligible to participate in this study if you have:
- Atypical or secondary parkinsonism
- Sleep apnea
- Restless legs syndrome
- Untreated hallucinations or psychosis
- Shift work now or within the last 3 months
- Traveled through 2 or more time zones within 90 days prior to screening
- Unstable/serious medical illness

Additional criteria for inclusion/exclusion will be assessed in a screening visit.
Institution  –  MGH - Massachusetts General Hospital, Boston, MA; Massachusetts General Hospital, Boston, MA
Principal Investigator  – Aleksandar Videnovic, MD, MSc
Enrollment Information
For further information about enrolling a patient in this trial, contact the person below.
Name  – Catherine Havemann
Phone  – 617-726-9589